In a coma, Stu Miley a cartoonist who created a comic strip called Monkeybone which features a rascal monkey. He finds himself trapped within his own underground creation and must find a way to get back, while racing against his popular but treacherous character, Monkeybone. Naturally, Monkeybone himself is there, and he and Stu quickly start fighting like cats and dogs. When Stu realizes that his sister, due to a pact they once made, is preparing to pull the plug on him, Stu makes a deal with Hypnos, the god of sleep, to help him steal a golden ticket from Death himself. But when Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!

When Coraline moves to an old house, she feels bored and neglected by her parents. She finds a hidden door with a bricked up passage. During the night, she crosses the passage and finds a parallel world where everybody has buttons instead of eyes, with caring parents and all her dreams coming true. When the Other Mother invites Coraline to stay in her world forever, the girl refuses and finds that the alternate reality where she is trapped is only a trick to lure her.